TY - JOUR AU - Ziv, Y. AU - Bielopolski, D. AU - Galanty, Y. AU - Lukas, C. AU - Taya, Y. AU - Schultz, D. C. AU - Lukas, J. AU - Bekker-Jensen, S. AU - Bartek, J. AU - Shiloh, Y. PY - 2006 DA - 2006// TI - Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway JO - Nat Cell Biol VL - 8 UR - https://doi.org/10.1038/ncb1446 DO - 10.1038/ncb1446 ID - Ziv2006 ER - TY - STD TI - Misteli T, Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol. 2009;10:243–54. ID - ref2 ER - TY - JOUR AU - Casafont, I. AU - Palanca, A. AU - Lafarga, V. AU - Berciano, M. T. AU - Lafarga, M. PY - 2011 DA - 2011// TI - Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle JO - Acta Neuropathol VL - 122 UR - https://doi.org/10.1007/s00401-011-0869-0 DO - 10.1007/s00401-011-0869-0 ID - Casafont2011 ER - TY - JOUR AU - Ferrer, I. AU - Serrano, T. AU - Alcantara, S. AU - Tortosa, A. AU - Graus, F. PY - 1993 DA - 1993// TI - X-ray-induced cell death in the developing hippocampal complex involves neurons and requires protein synthesis JO - J Neuropathol Exp Neurol VL - 52 UR - https://doi.org/10.1097/00005072-199307000-00004 DO - 10.1097/00005072-199307000-00004 ID - Ferrer1993 ER - TY - JOUR AU - Chow, H. M. AU - Herrup, K. PY - 2015 DA - 2015// TI - Genomic integrity and the ageing brain JO - Nat Rev Neurosci VL - 16 UR - https://doi.org/10.1038/nrn4020 DO - 10.1038/nrn4020 ID - Chow2015 ER - TY - JOUR AU - Pan, L. AU - Penney, J. AU - Tsai, L. H. PY - 2014 DA - 2014// TI - Chromatin regulation of DNA damage repair and genome integrity in the central nervous system JO - J Mol Biol VL - 426 UR - https://doi.org/10.1016/j.jmb.2014.08.001 DO - 10.1016/j.jmb.2014.08.001 ID - Pan2014 ER - TY - JOUR AU - Lieber, M. R. PY - 2010 DA - 2010// TI - The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway JO - Ann Rev Biochem. VL - 79 UR - https://doi.org/10.1146/annurev.biochem.052308.093131 DO - 10.1146/annurev.biochem.052308.093131 ID - Lieber2010 ER - TY - JOUR AU - Madabhushi, R. AU - Pan, L. AU - Tsai, L. H. PY - 2014 DA - 2014// TI - DNA damage and its links to neurodegeneration JO - Neuron VL - 83 UR - https://doi.org/10.1016/j.neuron.2014.06.034 DO - 10.1016/j.neuron.2014.06.034 ID - Madabhushi2014 ER - TY - JOUR AU - Sedelnikova, O. A. AU - Horikawa, I. AU - Zimonjic, D. B. AU - Popescu, N. C. AU - Bonner, W. M. AU - Barrett, J. C. PY - 2004 DA - 2004// TI - Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks JO - Nat Cell Biol VL - 6 UR - https://doi.org/10.1038/ncb1095 DO - 10.1038/ncb1095 ID - Sedelnikova2004 ER - TY - JOUR AU - Rass, U. AU - Ahel, I. AU - West, S. C. PY - 2007 DA - 2007// TI - Defective DNA repair and neurodegenerative disease JO - Cell VL - 130 UR - https://doi.org/10.1016/j.cell.2007.08.043 DO - 10.1016/j.cell.2007.08.043 ID - Rass2007 ER - TY - JOUR AU - Baltanas, F. AU - Casafont, I. AU - Lafarga, V. AU - Weruaga, E. AU - Alonso, J. R. AU - Berciano, M. T. AU - Lafarga, M. PY - 2011 DA - 2011// TI - Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M111.246041 DO - 10.1074/jbc.M111.246041 ID - Baltanas2011 ER - TY - JOUR AU - McKinnon, P. J. PY - 2013 DA - 2013// TI - Maintaining genome stability in the nervous system JO - Nat Neurosci VL - 16 UR - https://doi.org/10.1038/nn.3537 DO - 10.1038/nn.3537 ID - McKinnon2013 ER - TY - JOUR AU - Soria, G. AU - Polo, S. E. AU - Almouzni, G. PY - 2012 DA - 2012// TI - Prime, repair, restore: the active role of chromatin in the DNA damage response JO - Mol Cell VL - 46 UR - https://doi.org/10.1016/j.molcel.2012.06.002 DO - 10.1016/j.molcel.2012.06.002 ID - Soria2012 ER - TY - JOUR AU - Cavaletti, G. AU - Marmiroli, P. PY - 2010 DA - 2010// TI - Chemotherapy-induced peripheral neurotoxicity JO - Nat Rev Neurol VL - 6 UR - https://doi.org/10.1038/nrneurol.2010.160 DO - 10.1038/nrneurol.2010.160 ID - Cavaletti2010 ER - TY - JOUR AU - Palanca, A. AU - Casafont, I. AU - Berciano, M. T. AU - Lafarga, M. PY - 2014 DA - 2014// TI - Proteasome inhibition induces DNA damage and reorganizes nuclear architecture and protein synthesis machinery in sensory ganglion neurons JO - Cell Mol Life Sci VL - 71 UR - https://doi.org/10.1007/s00018-013-1474-2 DO - 10.1007/s00018-013-1474-2 ID - Palanca2014 ER - TY - JOUR AU - Pena, E. AU - Berciano, M. T. AU - Fernandez, R. AU - Ojeda, J. L. AU - Lafarga, M. PY - 2001 DA - 2001// TI - Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons JO - J Comp Neurol VL - 430 UR - https://doi.org/3.0.CO;2-L DO - 3.0.CO;2-L ID - Pena2001 ER - TY - JOUR AU - Fernandez-Capetillo, O. AU - Lee, A. AU - Nussenzweig, M. AU - Nussenzweig, A. PY - 2004 DA - 2004// TI - H2AX: the histone guardian of genome JO - DNA Repair VL - 3 UR - https://doi.org/10.1016/j.dnarep.2004.03.024 DO - 10.1016/j.dnarep.2004.03.024 ID - Fernandez-Capetillo2004 ER - TY - JOUR AU - Ismail, I. H. AU - Hendzel, M. J. PY - 2008 DA - 2008// TI - The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more? JO - Environ Mol Mutagen VL - 49 UR - https://doi.org/10.1002/em.20358 DO - 10.1002/em.20358 ID - Ismail2008 ER - TY - JOUR AU - Bothmer, A. AU - Robbiani, D. F. AU - Feldhahn, N. AU - Gazumyan, A. AU - Nussenzweig, A. AU - Nussenzweig, M. C. PY - 2010 DA - 2010// TI - 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination JO - J Exp Med VL - 207 UR - https://doi.org/10.1084/jem.20100244 DO - 10.1084/jem.20100244 ID - Bothmer2010 ER - TY - JOUR AU - Panier, S. AU - Boulton, S. J. PY - 2014 DA - 2014// TI - Double-strand break repair: 53BP1 comes into focus JO - Nat Rev Mol Cell Biol VL - 15 UR - https://doi.org/10.1038/nrm3719 DO - 10.1038/nrm3719 ID - Panier2014 ER - TY - JOUR AU - Stiff, T. AU - O’Driscoll, M. AU - Rief, N. AU - Iwabuchi, K. AU - Löbrich, M. AU - Jeggo, P. A. PY - 2004 DA - 2004// TI - ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-03-3207 DO - 10.1158/0008-5472.CAN-03-3207 ID - Stiff2004 ER - TY - JOUR AU - Mailand, N. AU - Bekker-Jensen, S. AU - Faustrup, H. AU - Melander, F. AU - Bartek, J. AU - Lukas, C. AU - Lukas, J. PY - 2007 DA - 2007// TI - RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins JO - Cell VL - 131 UR - https://doi.org/10.1016/j.cell.2007.09.040 DO - 10.1016/j.cell.2007.09.040 ID - Mailand2007 ER - TY - JOUR AU - Shanbhag, N. M. AU - Rafalska-Metcalf, I. U. AU - Balane-Bolivar, C. AU - Janicki, S. M. AU - Greenberg, R. A. PY - 2010 DA - 2010// TI - ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks JO - Cell VL - 141 UR - https://doi.org/10.1016/j.cell.2010.04.038 DO - 10.1016/j.cell.2010.04.038 ID - Shanbhag2010 ER - TY - JOUR AU - Henriksson, S. AU - Rassoolzadeh, H. AU - Hedström, E. AU - Coucoravas, C. AU - Julner, A. AU - Goldstein, M. AU - Imreh, G. AU - Zhivotovsky, B. AU - Kastan, M. B. AU - Helleday, T. AU - Farnebo, M. PY - 2014 DA - 2014// TI - The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair JO - Genes Dev VL - 28 UR - https://doi.org/10.1101/gad.246546.114 DO - 10.1101/gad.246546.114 ID - Henriksson2014 ER - TY - JOUR AU - Bernhard, W. PY - 1969 DA - 1969// TI - A new staining procedure for electron microscopical cytology JO - J Ultrastruct Res VL - 27 UR - https://doi.org/10.1016/S0022-5320(69)80016-X DO - 10.1016/S0022-5320(69)80016-X ID - Bernhard1969 ER - TY - JOUR AU - Lamond, A. I. AU - Spector, D. L. PY - 2003 DA - 2003// TI - Nuclear speckles: a model for nuclear organelles JO - Nat Rev Mol Cell Biol VL - 4 UR - https://doi.org/10.1038/nrm1172 DO - 10.1038/nrm1172 ID - Lamond2003 ER - TY - JOUR AU - Dorigo, B. AU - Schalch, T. AU - Kulangara, A. AU - Duda, S. AU - Schroeder, R. R. AU - Richmond, T. J. PY - 2004 DA - 2004// TI - Nucleosome arrays reveal the two-start organization of the chromatin fiber JO - Science VL - 306 UR - https://doi.org/10.1126/science.1103124 DO - 10.1126/science.1103124 ID - Dorigo2004 ER - TY - JOUR AU - Raska, I. AU - Shaw, P. J. AU - Cmarko, D. PY - 2006 DA - 2006// TI - New insights into nucleolar architecture and activity JO - Int Rev Cytol VL - 255 UR - https://doi.org/10.1016/S0074-7696(06)55004-1 DO - 10.1016/S0074-7696(06)55004-1 ID - Raska2006 ER - TY - JOUR AU - Jonkers, I. AU - Lis, J. T. PY - 2015 DA - 2015// TI - Getting up to speed with transcription elongation by RNA polymerase II JO - Nat Rev Mol Cell Biol VL - 16 UR - https://doi.org/10.1038/nrm3953 DO - 10.1038/nrm3953 ID - Jonkers2015 ER - TY - JOUR AU - Guillot, P. V. AU - Xie, S. Q. AU - Hollinshead, M. AU - Pombo, A. PY - 2004 DA - 2004// TI - Fixation-induced redistribution of hyperphosphorylated RNA polymerase II in the nucleus of human cells JO - Exp Cell Res VL - 295 UR - https://doi.org/10.1016/j.yexcr.2004.01.020 DO - 10.1016/j.yexcr.2004.01.020 ID - Guillot2004 ER - TY - JOUR AU - Raska, I. AU - Ochs, R. L. AU - Andrade, L. E. AU - Chan, E. K. AU - Burlingame, R. AU - Peebles, C. AU - Gruol, D. AU - Tan, E. M. PY - 1990 DA - 1990// TI - Association between the nucleolus and the coiled body JO - J Struct Biol VL - 104 UR - https://doi.org/10.1016/1047-8477(90)90066-L DO - 10.1016/1047-8477(90)90066-L ID - Raska1990 ER - TY - JOUR AU - Carvalho, T. AU - Almeida, F. AU - Calapez, A. AU - Lafarga, M. AU - Berciano, M. T. AU - Carmo-Fonseca, M. PY - 1999 DA - 1999// TI - The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body JO - J Cell Biol VL - 147 UR - https://doi.org/10.1083/jcb.147.4.715 DO - 10.1083/jcb.147.4.715 ID - Carvalho1999 ER - TY - JOUR AU - Cioce, M. AU - Lamond, A. I. PY - 2005 DA - 2005// TI - Cajal bodies: a long history of discovery JO - Annu Rev Cell Dev Biol VL - 21 UR - https://doi.org/10.1146/annurev.cellbio.20.010403.103738 DO - 10.1146/annurev.cellbio.20.010403.103738 ID - Cioce2005 ER - TY - JOUR AU - Suberbielle, E. AU - Sanchez, P. E. AU - Kravitz, A. V. AU - Wang, X. AU - Ho, K. AU - Eilertson, K. AU - Devidze, N. AU - Kreitzer, A. C. AU - Mucke, L. PY - 2013 DA - 2013// TI - Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β JO - Nat Neurosci VL - 16 UR - https://doi.org/10.1038/nn.3356 DO - 10.1038/nn.3356 ID - Suberbielle2013 ER - TY - JOUR AU - Canugovi, C. AU - Misiak, M. AU - Ferrarelli, L. K. AU - Croteau, D. L. AU - Bohr, V. A. PY - 2013 DA - 2013// TI - The role of DNA repair in brain related disease pathology JO - DNA Repair VL - 12 UR - https://doi.org/10.1016/j.dnarep.2013.04.010 DO - 10.1016/j.dnarep.2013.04.010 ID - Canugovi2013 ER - TY - JOUR AU - Madabhushi, R. AU - Gao, F. AU - Pfenning, A. R. AU - Pan, L. AU - Yamakawa, S. AU - Seo, J. AU - Rueda, R. AU - Phan, T. X. AU - Yamakawa, H. AU - Pao, P. C. AU - Stott, R. T. AU - Gjoneska, E. AU - Nott, A. AU - Cho, S. AU - Kellis, M. AU - Tsai, L. H. PY - 2015 DA - 2015// TI - Activity-induced DNA breaks govern the expression of neuronal early-response genes JO - Cell VL - 1617 UR - https://doi.org/10.1016/j.cell.2015.05.032 DO - 10.1016/j.cell.2015.05.032 ID - Madabhushi2015 ER - TY - JOUR AU - Austin, C. A. AU - Marsh, K. L. PY - 1998 DA - 1998// TI - Eukaryotic DNA topoisomerase II beta JO - Bioessays VL - 20 UR - https://doi.org/3.0.CO;2-Q DO - 3.0.CO;2-Q ID - Austin1998 ER - TY - JOUR AU - Cavanagh, J. B. AU - Tomiwa, K. AU - Munro, P. M. PY - 1987 DA - 1987// TI - Nuclear and nucleolar damage in adriamycin-induced toxicity to rat sensory ganglion cells JO - Neuropathol Appl Neurobiol VL - 13 UR - https://doi.org/10.1111/j.1365-2990.1987.tb00168.x DO - 10.1111/j.1365-2990.1987.tb00168.x ID - Cavanagh1987 ER - TY - JOUR AU - Pena, E. AU - Berciano, M. T. AU - Fernandez, R. AU - Crespo, P. AU - Lafarga, M. PY - 2000 DA - 2000// TI - Stress-induced activation of c-Jun N-terminal kinase in sensory ganglion neurons: accumulation in nuclear domains enriched in splicing factors and distribution in perichromatin fibrils JO - Exp Cell Res VL - 256 UR - https://doi.org/10.1006/excr.2000.4814 DO - 10.1006/excr.2000.4814 ID - Pena2000 ER - TY - JOUR AU - Casafont, I. AU - Navascués, J. AU - Pena, E. AU - Lafarga, M. AU - Berciano, M. T. PY - 2006 DA - 2006// TI - Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5’-fluororidine into nascent RNA JO - Neuroscience VL - 140 UR - https://doi.org/10.1016/j.neuroscience.2006.02.030 DO - 10.1016/j.neuroscience.2006.02.030 ID - Casafont2006 ER - TY - JOUR AU - Alberti, P. AU - Cavaletti, G. PY - 2014 DA - 2014// TI - Management of side effects in the personalized medicine era: chemotherapy-induced peripheral neuropathy JO - Methods Mol Biol VL - 1175 UR - https://doi.org/10.1007/978-1-4939-0956-8_12 DO - 10.1007/978-1-4939-0956-8_12 ID - Alberti2014 ER - TY - STD TI - Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, et al. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol. 2006;172:823–34. ID - ref42 ER - TY - JOUR AU - Dellaire, G. AU - Kepkay, R. AU - Bazett-Jones, D. P. PY - 2009 DA - 2009// TI - High resolution imaging of changes in the structure and spatial organization of chromatin, γ-H2AX and the MRN complex within etoposide-induced DNA repair foci JO - Cell Cycle VL - 8 UR - https://doi.org/10.4161/cc.8.22.10065 DO - 10.4161/cc.8.22.10065 ID - Dellaire2009 ER - TY - JOUR AU - Luijsterburg, M. S. AU - Attikum, H. PY - 2011 DA - 2011// TI - Chromatin and the DNA damage response: the cancer connection JO - Mol Oncol VL - 5 UR - https://doi.org/10.1016/j.molonc.2011.06.001 DO - 10.1016/j.molonc.2011.06.001 ID - Luijsterburg2011 ER - TY - JOUR AU - Maison, C. AU - Almouzni, G. PY - 2004 DA - 2004// TI - HP1 and the dynamics of heterochromatin maintenance JO - Nat Rev Mol Cell Biol VL - 5 UR - https://doi.org/10.1038/nrm1355 DO - 10.1038/nrm1355 ID - Maison2004 ER - TY - JOUR AU - Tremethick, D. J. PY - 2007 DA - 2007// TI - Higher-order structures of chromatin: the elusive 30 nm fiber JO - Cell VL - 128 UR - https://doi.org/10.1016/j.cell.2007.02.008 DO - 10.1016/j.cell.2007.02.008 ID - Tremethick2007 ER - TY - JOUR AU - Moyal, L. AU - Lerenthal, Y. AU - Gana-Weisz, M. AU - Mass, G. AU - So, S. AU - Wang, S. Y. AU - Eppink, B. AU - Chung, Y. M. AU - Shalev, G. AU - Shema, E. AU - Shkedy, D. AU - Smorodinsky, N. I. AU - Vliet, N. AU - Kuster, B. AU - Mann, M. AU - Ciechanover, A. AU - Dahm-Daphi, J. AU - Kanaar, R. AU - Hu, M. C. AU - Chen, D. J. AU - Oren, M. AU - Shiloh, Y. PY - 2011 DA - 2011// TI - Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks JO - Mol Cell VL - 41 UR - https://doi.org/10.1016/j.molcel.2011.02.015 DO - 10.1016/j.molcel.2011.02.015 ID - Moyal2011 ER - TY - JOUR AU - Caron, P. AU - Aymard, F. AU - Iacovoni, J. S. AU - Briois, S. AU - Canitrot, Y. AU - Bugler, B. AU - Massip, L. AU - Losada, A. AU - Legube, G. PY - 2012 DA - 2012// TI - Cohesin protects genes against γH2AX induced by DNA double-strand breaks JO - PLoS Genet VL - 8 UR - https://doi.org/10.1371/journal.pgen.1002460 DO - 10.1371/journal.pgen.1002460 ID - Caron2012 ER - TY - JOUR AU - Aten, J. A. AU - Stap, J. AU - Krawczyk, P. M. AU - Oven, C. H. AU - Hoebe, R. A. AU - Essers, J. AU - Kanaar, R. PY - 2004 DA - 2004// TI - Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains JO - Science VL - 303 UR - https://doi.org/10.1126/science.1088845 DO - 10.1126/science.1088845 ID - Aten2004 ER - TY - JOUR AU - Zhang, Y. AU - Heermann, D. W. PY - 2014 DA - 2014// TI - DNA double-strand breaks: linking gene expression to chromosome morphology and mobility JO - Chromosoma VL - 123 UR - https://doi.org/10.1007/s00412-013-0432-y DO - 10.1007/s00412-013-0432-y ID - Zhang2014 ER - TY - JOUR AU - Torres-Rosell, J. AU - Sunjevaric, I. AU - Piccoli, G. AU - Sacher, M. AU - Eckert-Boulet, N. AU - Reid, R. AU - Jentsch, S. AU - Rothstein, R. AU - Aragón, L. AU - Lisby, M. PY - 2007 DA - 2007// TI - The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus JO - Nat Cell Biol VL - 9 UR - https://doi.org/10.1038/ncb1619 DO - 10.1038/ncb1619 ID - Torres-Rosell2007 ER - TY - STD TI - Chiolo I, Minoda A, Colmenares SU, Polyzos A, Costes SV, Karpen GH. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 2011;144732–44. ID - ref52 ER - TY - JOUR AU - Casafont, I. AU - Palanca, A. AU - Lafarga, V. AU - Mata-Garrido, J. AU - Berciano, M. T. AU - Lafarga, M. PY - 2015 DA - 2015// TI - Behavior of the RNA Polymerase II and the Ubiquitin Proteasome system during the neuronal DNA damage response to ionizing radiation JO - Mol Neurobiol ID - Casafont2015 ER - TY - JOUR AU - Padeken, J. AU - Heun, P. PY - 2014 DA - 2014// TI - Nucleolus and nuclear periphery: velcro for heterochromatin JO - Curr Opin Cell Biol VL - 28 UR - https://doi.org/10.1016/j.ceb.2014.03.001 DO - 10.1016/j.ceb.2014.03.001 ID - Padeken2014 ER - TY - STD TI - Smirnov E, Cmarko D, Mazel T, Hornáček M, Raška I. Nucleolar DNA: the host and the guests. Histochem Cell Biol. 2016;145:359-72. ID - ref55 ER - TY - JOUR AU - Jakob, B. AU - Splinter, J. AU - Conrad, S. AU - Voss, K. O. AU - Zink, D. AU - Durante, M. AU - Löbrich, M. AU - Taucher-Scholz, G. PY - 2011 DA - 2011// TI - DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin JO - Nucleic Acids Res VL - 39 UR - https://doi.org/10.1093/nar/gkr230 DO - 10.1093/nar/gkr230 ID - Jakob2011 ER - TY - JOUR AU - Harding, S. M. AU - Boiarsky, J. A. AU - Greenberg, R. A. PY - 2015 DA - 2015// TI - ATM dependent silencing links nucleolar chromatin reorganization to DNA damage recognition JO - Cell Rep VL - 13 UR - https://doi.org/10.1016/j.celrep.2015.08.085 DO - 10.1016/j.celrep.2015.08.085 ID - Harding2015 ER -