Clobetasol promotes remyelination in a mouse model of neuromyelitis optica

Table 1 Compounds with reported remyelinating activity

Compound	Model systems	Proposed mechanisms	References
Benztropine	EAE, cuprizone mouse model	Muscarinic agonist	[8]
CDP-choline	EAE, cuprizone mouse model	Protein kinase C-mediated OPC proliferation	[37]
Clemastine	Lysolecithin mouse model	Antihistamine, anticholinergic	[20]
Clobetasol	Lysolecithin model, EAE	Glucocorticoid receptor signaling, Hedgehog signaling, OPC differentiation	[10, 24, 27, 34, 44]
Enprofylline	Kainic acid-induced spinal cord injury ex vivo	Adenosine receptor antagonist	[21]
Fasudil	OPC culture	Rho-kinase inhibitor, vasodilator	[2]
GC-1	OPC culture/P7 mouse model of myelination	Thyroid receptor agonist, OPC differentiation	[4]
Indazole	EAE	Estrogen receptor beta agonist	[22]
Miconazole	Lysolecithin model, EAE	ERK1/2 activator, OPC differentiation	[14, 24]
Olesoxime	Lysolecithin mouse model, cuprizone mouse model	Mitochondrial pore modulator	[18]
Quercetin	EAE	γ-secretase inhibition interfering with canonical Notch signaling	[15]
Quetiapine	EAE, cuprizone model, cerebral ischemia	Free radical scavenging, neurotrophic factor stimulation	[51]
Retinoic acid	Lysolecithin model, ethidium bromide model	Retinoid X receptor γ agonist	[13]
Y-27632	Lysolecithin in cerebellar slice cultures	Rho-kinase inhibitor	[31]

ISSN: 2051-5960