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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Clobetasol promotes remyelination in a mouse model of neuromyelitis optica

Fig. 4

Clobetasol reduces myelin loss in a mouse model of NMO produced by intracerebral injection of AQP4-IgG and human complement. a. Protocol showing AQP4-IgG (or control IgG) injected at day 0, with clobetasol (or vehicle) treatment given from days 1 to 9. b. Gallery of micrographs showing AQP4, MBP and NF immunofluorescence for three clobetasol- and three vehicle-treated mice. c. Representative immunofluorescence with high magnification of AQP4, MBP and NF (left); summary of area of loss of immunofluorescence (normalized to total area of brain hemisphere) (mean ± S.E., 6 mice per group, ** P < 0.01) (right). d. Immunofluorescence for indicated markers. e. High-magnification confocal microscopy showing MBP, CC1 and Olig2 immunofluorescence (left), with quantitative data of CC1-positive cells per mm2 (mean ± S.E., 3 mice per group, six fields per section, ** P < 0.01) (right)

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