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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy

Fig. 3

Overall- and progression free survival of 57 PCNSL CCT-treated patients subjected to TP53 mutation analysis. Patients with MUT-TP53 (red) (n = 24) showed a non-significant trend towards worse (a) OS, and (b) PFS compared to patients with WT-TP53 (blue), P = 0.16 and P = 0.10, respectively. Presence of a TP53 hotspot/or direct DNA contact mutations (n = 9) was indicative of poorer (c) OS, and (d) PFS compared to patients with non-hotspot/non-direct DNA contact TP53 mutations and WT-TP53, P = 0.041 and P = 0.00076, respectively

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Acta Neuropathologica Communications

ISSN: 2051-5960

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