Fig. 1

Global analysis of C9orf72 expression using CAGEseq expression data from the FANTOM5 project. Boxplots showing total C9orf72 expression at the C9orf72 locus from the sense (a) and antisense (b) strand in myeloid, lymphoid and CNS samples available in the FANTOM5 promoterome sample collection. C9orf72 expression is particularly high in a subset of myeloid cells (CD14+ monocytes, eosinophils and neutrophils) indicated as myeloid-high and lower in macrophages and mast cells (myeloid-low), T and B cells (lymphoid cells) and tissues from the CNS. Expression values are indicated on the Y-axes as tpm. Total expression at C9orf72 locus deriving from the sense strand (reverse or -) was calculated by adding the expression of all the TSSs on the reverse strand (i.e. S1 + S3b, S1 + S3a, S2A, S2B, S2C and S4) for all the libraries included in the study. Similarly total expression deriving from the antisense strand (forward or +) was calculated adding the expression of all the TSSs located on the forward strand (i.e. AS1, AS2 and AS3)