Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 4 Distribution and severity of neurodegenerative changes in patients with BIBD

From: Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

  Cases with chorea Cases without chorea
  1 2 3 4 5 6
Brain weight (g) 800 1190 880 1140 940 1230
Cortical atrophy F, T(base) F(tip) F&T(base) F&T(base) F,T(base) T(tip)
Frontal cortex +++ +++ ++ +++ +++ +++
Cingulate gyrus +++ +++ +++ +++ +++ +++
Temporal cortex ++ + ++ ++ +++ +++
Hippocampus +++ + +++ +++ na +++
Amygdala +++ + na +++ +++ +++
Caudate nucleus +++ +++ +++ +++ +++ +++
Putamen +++ + +++ ++ +++ +++
Globus pallidus +++ ± ++ ++ ++ ++
Thalamus +++ ± ± ++ +++ +
Subthalamic nucleus ± ± ± ± ± ±
Nucleus basalis of Meynert + - ± ± ± +
Cerebellar dentate nucleus ± - ± ± ± +
Red nucleus ± ± ± na na ±
Substantia nigra +++ + +++ ++ +++ +++
Locus coeruleus +++ - ± ± ++ ++
Pontine nucleus ± ± ± ± ± ±
Dorsal vagal nucleus ± ± ± na ± ±
Hypoglossal nucleus ± - ± ± ± ±
Inferior olivary nucleus ± ± ± ± + +
Spinal cord - - na na na ±
  1. Data for cases 2 through 6 were assembled from previously published materials [15, 29]. F, frontal lobe; T, temporal lobe; F(tip), frontal tip; F(base), frontal base, T(tip), temporal tip; T(base), temporal base. Rating for the severity of degeneration: -, no degeneration; ±, no neuronal loss but gliosis; +, slight neuronal loss and gliosis; ++, moderate neuronal loss and gliosis; +++, severe neuronal loss and gliosis. Degeneration in the corticospinal tract: +, present; -, absent. na, tissue not available