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Table 1 Molecular pathology of 72 FTLD cases

From: Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

Diagnosis

No. of patients

FTLD-tau (29)

 

 Pick’s diseasea

18

 FTDP-17tau

1

 CBDb

4

 PSPb

4

 Unclassifiable

2, [53]

FTLD-TDP (32)c

 

 Type A

4

 Type B

17

 Type C

10

 Unclassifiable

1, [54]

FTLD-FUS (10)

 

 BIBD

6

 NIFID

2

 aFTLD-U

1

 Unclassifiable

1, [55]

Unclassifiable (1)

 
  1. CBD corticobasal degeneration, PSP progressive supranuclear palsy, FTDP-17tau frontotemporal dementia with parkinsonism linked to chromosome 17 associated with tau pathology, BIBD basophilic inclusion body disease, NIFID neuronal intermediate filament inclusion disease; aFTLD-U atypical FTLD with ubiquitinated inclusions
  2. aPick’s disease refers to only FTLD-tau with Pick bodies
  3. bCases with CBD and PSP were included only if the patients presented with features of FTLD, such as frontotemporal dementia, semantic dementia and progressive nonfluent aphasia
  4. cFTLD-TDP cases were classified using the system reported by Mackenzie et al. [56]
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Acta Neuropathologica Communications

ISSN: 2051-5960

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