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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration

Fig. 6

Biochemical analysis of FUS. Proteins were sequentially extracted from brains of patients with BIBD, aFTLD-U, NIFID, and from a control subject. Fractions from patients diagnosed as BIBD with chorea (case 1, lane 1), aFTLD-U (case 9, lane 2), or NIFID (case 8, lane 3) and the control patient (lane 4) were separated by 7.5 % SDS-PAGE and immunoblotted with anti-FUS antibodies (a A300-302A; b HPA008784). All cases, including the control, show a strong 73-kDa band (white arrow) in both soluble and insoluble high-salt fractions. Additionally, the BIBD with chorea patient has a strong band at approximately 33 kDa (black arrow; b TX-ppt, lane 1), which is less prominent in the other samples

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