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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy

Fig. 5

Sphingosine-1-phosphate (S1P) treatment does not affect the dynamics of granule cell dendrites in non-denervated control cultures. a, b Application of exogenous S1P (1 μM) into the incubation medium did not reduce the total dendritic length (TDL) of dentate granule cells in non-denervated cultures a and did not cause dendritic destabilization, i.e., changes in dendritic elongation and retraction b (n = 6 neurons per group; one cell per culture; statistically compared against untreated controls, pooled, taken from Fig. 2; Kruskal-Wallis-test followed by Dunn’s post-hoc-test; ns, not significant). c Schematic illustration of the stability model of denervation-induced dendritic remodeling. The results of the present study demonstrate that partial deafferentation leads to profound changes in dendritic stability. Both, elongation and retraction of dendritic segments are increased after entorhinal denervation. During the early phase, retraction exceeds elongation, which results in a reduction of TDL. At a later stage elongation surpasses retraction and TDL recovers. Our data suggest that S1P-receptor signaling prevents these denervation-induced changes in dendritic stability and, thus, changes in TDL

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