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Table 2 Mean (±SD) values for age at onset of symptoms, age at death and duration of illness for patients with Motor Neurone Disease (MND), behavioural variant Frontotemporal Dementia and Motor Neurone Disease (FTD + MND) and FTD. Also shown are mean (±SD) values for age at onset of symptoms, age at death and duration of illness for those cases of MND, FTD + MND and FTD, collectively, with mutations in GRN, expansion in C9orf72, or no known mutation, along with mean (±SD) values for age at onset of symptoms, age at death and duration of illness for those cases of MND, FTD + MND and FTD, collectively, showing with and without amyloid pathology, and those with and without (any type of) tau pathology

From: Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy

Group

Age at onset (y)

Age at death (y)

Duration of illness (y)

MND (n = 41)

57.2 ± 12.2

60.1 ± 12.0*

2.9 ± 1.4**

FTD + MND (n = 16)

59.8 ± 9.4

63.1 ± 9.4

3.4 ± 2.4**

FTD (n = 23)

60.7 ± 5.7

69.3 ± 4.9

8.8 ± 3.7

GRN mutation (n = 12)

59.7 ± 5.5

69.3 ± 3.6

9.7 ± 4.2

C9orf72 expansion (n = 15)

57.7 ± 7.1

62.9 ± 7.1

5.2 ± 3.0!!!

No genetic mutation (n = 53)

59.2 ± 11.4

62.7 ± 11.8

3.5 ± 2.4!!!

All cases with amyloid (n = 21)

64.2 ± 8.1$$

70.0 ± 7.2$$$

5.8 ± 4.2

All cases without amyloid (n = 59)

57.5 ± 9.8

62.2 ± 10.4

4.7 ± 3.5

All cases with tau (n = 41)

60.7 ± 10.4

65.1 ± 10.5

4.4 ± 2.7

All cases without tau (n = 39)

57.4 ± 9.0

60.7 ± 10.4

5.4 ± 4.4

  1. *, ** indicate significantly different from FTD group, p = 0.003 and p < 0.001, respectively
  2. !!! indicates significantly different from GRN mutation group, p < 0.001
  3. $$, $$$ indicate significantly older than cases without amyloid, p = 0.003, <0.001, respectively