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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy

Fig. 5

Immunoblot analysis of sarkosyl-insoluble tau extracted from temporal cortex, and detected by T46 (anti-tau C-terminus) antibody. MND tau group 1 (patients #30 and 35) (lanes 1 and 2, respectively) and group 2 (patient #40) (lane 3) show an Alzheimer’s disease-like triplet banding pattern comprising bands of hyperphosphorylated full-length tau at 60, 64 and 68 kDa, though various C-terminal fragments and smears are also detected. In contrast, the banding pattern in MND tau group 3 patients (patient #41) with Argyrophilic Grain Disease (lane 4) is characteristic of 4-R tauopathy with major bands at 64 and 68 kDa

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