Fig. 4

Neurofibrillary tangles and neuropil threads in entorhinal (a) and frontal (b) cortex in MND tau group 1 patients are immunoreactive for both 3-R (not shown) and 4-R tau (a, b) proteins. Amorphous tau deposits in neurones of frontal cortex in MND tau group 2 patients (patient #38) are 4-R (c), but not 3-R tau (not shown) immunoreactive. Neurofibrillary tangles and amorphous tau deposits in CA2 neurones in MND tau group 3 patients are both 4-R tau immunoreactive (d). Neurofibrillary tangles are also 3-R tau immunoreactive (not shown). Argyrophilic grains in CA1 region of hippocampus (e) and oligodendroglial tangles in underlying white matter (f) are both immunoreactive for 4-R tau (e, f) but not 3-R tau (not shown). Immunoperoxidase, x400 microscope magnification