Fig. 5

Propagation of tau pathology to anatomically distinct brain regions. Regions of interest for analysis are taken from a lateral amygdala (LA), somatosensory cortex (SSC) and hippocampus (HC) in sections at the level of injection and d perirhinal cortex (Prh cx), caudate putamen (CPu) and motor cortex (Mtr cx) from sections anterior to the injection site at Bregma + 0.14 mm. Quantification of percentage area analysis at 24 h b, e shows significant increase in phospho-tau immunoreactivity in both the ipsilateral (ipsi) and contralateral (contra) hemispheres of OA-injected mice. By 7 days significant changes are predominately noted in the ipsilateral hemisphere (c) with the exception of the perirhinal cortex (f). (n = 4–5, *P < 0.05, **P < 0.01, ****P < 0.0001)