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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions

Fig. 3

Propagation of tau phosphorylation occurs across hemispheres at 24 h at remains up to 7 days. Representative images of AT180 immunoreactivty are taken from Bregma – 1.94 at the coronal level of injection. Tau phosphorylation at AT180 is observed in both the injected and contralateral hemisphere at 24 h post OA injection. Positive neurones and neuropil staining is abundant in both the lateral amygdala and hippocampus. Furthermore positive cell bodies and processes are clearly defined in the somatosensory cortex, although qualitatively more are seen in the injected hemisphere. By 7 days phospho-tau positive neurones are predominately observed in the injected hemisphere in fewer numbers than at 24 h. Phosphorylation does not persist in the hippocampus at 7 days. Scale bar = 50 μm

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