High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction

Table 1 The time course of Pα-syn expression in neurons and the number of motor neurons and myelinated fibers of Pla2g6-knockout (KO) mice

		Wt		KO
		2y (n = 4)	15w (n = 3)	1y (n = 4)	2y (n = 5)
Number of neurons filled with PαSyn (+) granules		0	12 (10)	0	0
Number of AHCs		44 (6)	n.e.	44 (2)	33 (10)
Sciatic nerve (distal axon)	Density of myelinated fibers	17567 (1513)	n.e.	14281 (2086)	18850 (1745)
Sciatic nerve (distal axon)	Density of large myelinated fibers	1623 (314)	n.e.	613 (172)	156* (104)

PαSyn phosphorylated α-synuclein, Wt wild-type, KO Pla2g6-knockout, 15 w 15 weeks, 1 y 1 year, 2y 2 years, AHC anterior horn cell, number of anterior horn cells mean (SD), n.e. not examined, Density of myelinated fibers number of myelinated fibers per mm², large myelinated fibers myelinated fibers with a diameter larger than 10 μm, *p <0.05

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