Fig. 7
From: High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction
Strong expression of a mitochondrial outer membrane protein (TOM20) on the surface of Lewy bodies (LBs) in PLA2G6-associated neurodegeneration (PLAN). The left and the right images show the dorsal nuclei of the vagus in a patient with PLAN. The center image shows the substantia nigra in a patient with Parkinson disease (PD). TOM20 20-kDa translocase of the outer mitochondrial membrane, SN substantia nigra, LC locus coeruleus, nX the dorsal nuclei of vagus, PD Parkinson disease, PLAN PLA2G6-associated neurodegeneration, LBs Lewy bodies, TOM20 (−) TOM20-negative, partially (+) partially TOM20-positive, completely (+) completely TOM20-positive, number of LBs * mean (SD)