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Table 1 Histopathological scoring of pneumococcal meningitis

From: Pneumococcal meningitis: Clinical-pathological correlations (meningene-path)

Scoring criteria

 

Scores

   

Main category

Subcategory

0

1

2

3

Meningeal infiltration

 

Absent

Focal mild infiltration

Multifocal mild or focal severe infiltration

Multifocal severe infiltration

Parenchymal damage

Parenchymal infiltration of inflammatory cells

Absent

Focal mild infiltration

Multifocal mild or focal severe infiltration

Multifocal severe infiltration

 

Infarction

Absent

Focal small damage

Multifocal small or focal large inflammation

Multifocal large damages

Haemorrhage

Abscess

 

Vascular inflammation

Large meningeal artery inflammation

Absent

Focal mild (sub)endothelial infiltration/reactive changes

Multifocal mild (sub)endothelial infiltration/reactive changes or focal severe (sub)-endothelial infiltration with obstruction of vascular lumen and/or extension of infiltration in the media layer

Multifocal severe (sub)endothelial infiltration with obstruction of vascular lumen and/or extension of infiltration in the media layer

Small parenchymal vessel inflammation

Thrombosis

Arterial thrombosis

Absent

Focal mild with partial obstruction of vascular lumen

Multifocal mild with partial obstruction of vascular lumen or focal severe with complete obstruction of vascular lumen and destruction of vessel wall

Multifocal severe with complete obstruction of vascular lumen and destruction of vessel wall

Venous thrombosis

Small vessel thrombosis

 

Ventriculitis

 

Absent

A few inflammatory cells in the ventricle

Groups of inflammatory cells in the ventricle with/without ependymal infiltration

Extension of inflammatory cells into the periventricular tissue