Fig. 2
From: Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse
STORM imaging of γ-secretase in synapses. (a) Localization of active γ-secretase at the presynaptic zone showing γ-secretase (red) and the presynaptic marker synaptophysin (blue). The upper left panel shows a typical STORM image on a brightfield overlay to the left, with increased zooming in the middle and right panels, displaying an individual synaptic region to the right. The lower panel shows the same synapse displayed in 3D view from three different angles where red, green and blue lines represent X, Y and Z directions, respectively. (b) Localization of active γ-secretase at the postsynaptic zone showing γ-secretase (red) and the postsynaptic marker PSD95 (blue). The upper left panel shows a typical STORM image on a brightfield overlay to the left, with increased zooming in the middle and right panels. The lower panel shows the same synapse displayed in 3D view from three different angles where red, green and blue lines in the symbol represent X, Y and Z directions, respectively