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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner

Fig. 3

CASK (+/-) heterozygous mutant mice display postnatal microcephaly, cerebellar hypoplasia and optic nerve hypoplasia. a Representative brain images of the sex-matched CASK (+/+) and CASK (+/-) mutant littermates at postnatal day 1 and day 75 (P1 and P75), respectively. b Quantitation of brain weights from CASK (+/+) and CASK (+/-) mice at P1 and P75 (* indicates p < 0.05; n = 4). c Hematoxylin and eosin (H&E) stained sections of hippocampus derived from CASK (+/+) and CASK (+/-) mice at P75; note the hippocampi sizes are comparable. d H&E stained sections of the cerebellum at P75 showing pronounced cerebellar hypoplasia in CASK (+/-) mice relative to the CASK (+/+) control. e High magnification of the indicated square regions from panel D showing relatively fewer cells in the cerebellar folia of CASK (+/-) mice compared to the CASK (+/+) control. f Left panel shows representative images of the optic globe and optic nerve derived from three month old CASK (+/+) and CASK (+/-) mice . Right panel shows the optic nerve cross section stained with anti-tubulin antibody from CASK (+/+) and CASK (+/-) mice; note the decrease in optic nerve diameter . Scale bar = 100 μm. g Quantification of the cerebellar and hippocampal areas and the optic nerve and optic globe diameters obtained from CASK (+/+) and CASK (+/-) mice. Measurements were made using Image J software and normalized to the sex-matched wild-type littermate controls. Bar graphs are plotted as mean ± SEM; (* indicates p< 0.05; n = 4)

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