Table 1 Clinical and pathological data of sporadic AD cases and non-demented controls. Aβ staining intensity: - no staining; (+) barely detectable staining, + weak staining, ++ moderate staining, +++ abundant staining; NP neuritic plaques
4G8 | Aβ37 | Aβ38 | Aβ39 | Aβ40 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | Age | Sex | Braak | Diagnosis | ApoE | NP | CAA | NP | CAA | NP | CAA | NP | CAA | NP | CAA |
#1 | 92 | M | IV | AD | 3/3 | ++ | + | - | - | - | + | - | + | + | + |
#2 | 92 | F | IV | AD | 3/3 | + | ++ | - | - | - | + | - | - | + | + |
#3 | 93 | M | IV | AD | 3/3 | + | +++ | - | +++ | - | ++ | - | ++ | ++ | +++ |
#4 | 91 | M | IV | AD | 4/2 | ++ | +++ | - | + | - | + | - | - | ++ | +++ |
#5 | 84 | F | IV | AD | 4/3 | ++ | + | - | + | - | ++ | - | ++ | + | ++ |
#6 | 91 | F | IV | AD | 4/3 | ++ | ++ | - | ++ | (+) | + | - | + | ++ | +++ |
#7 | 88 | F | IV | AD | 3/3 | + | + | - | - | - | - | - | - | + | + |
#8 | 92 | F | IV | AD | 4/2 | ++ | ++ | - | + | (+) | + | - | + | + | ++ |
#9 | 79 | F | IV | AD | 4/3 | ++ | +++ | (+) | ++ | (+) | +++ | - | ++ | ++ | +++ |
#10 | 84 | F | IV | AD | 3/2 | ++ | - | - | - | - | - | - | - | + | - |
#11 | 91 | F | IV | AD | 4/3 | ++ | + | - | (+) | - | - | - | (+) | (+) | + |
#12 | 86 | M | IV | AD | 3/3 | + | ++ | - | +++ | - | ++ | - | +++ | + | ++ |
#13 | 88 | F | IV | AD | 3/3 | ++ | + | - | - | - | - | - | - | - | + |
#14 | 96 | F | V | AD + CAA | 4/3 | ++ | +++ | - | + | - | +++ | - | ++ | ++ | +++ |
#15 | 82 | F | V | AD + CAA | 3/3 | ++ | +++ | - | ++ | - | +++ | + | +++ | +++ | +++ |
#16 | 61 | F | VI | DS | 3/3 | ++ | - | - | - | - | - | - | - | + | - |
#17 | 58 | M | VI | DS | 4/3 | ++ | ++ | (+) | + | + | + | - | - | ++ | ++ |
#18 | 64 | F | V | DS | 3/3 | ++ | ++ | - | ++ | - | ++ | - | ++ | ++ | ++ |
#19 | 91 | M | I | NDC | 3/3 | - | - | - | - | - | - | - | - | - | - |
#20 | 78 | F | I | NDC | 3/3 | (+) | - | - | - | - | - | - | - | - | + |
#21 | 73 | M | 0 | NDC | 3/3 | - | - | - | - | - | - | - | - | - | - |
#22 | 84 | M | I | NDC | 3/3 | - | - | - | - | - | - | - | - | - | - |
#23 | 88 | F | I | NDC | 3/3 | + | - | - | - | - | - | - | - | - | - |
#24 | 78 | M | I | NDC | 4/3 | ++ | + | - | - | - | + | - | - | + | ++ |
#25 | 82 | F | I | NDC | 3/3 | - | - | - | - | - | - | - | - | - | - |
#26 | 70 | M | 0 | NDC | 3/2 | - | - | - | - | - | - | - | - | - | - |