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Table 1 Serum analysis demonstrates M1 treatment is associated with reduced circulating C1q

From: C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

 

MFS model

AMAN model

M1 (n=4) control mAb (n=3)

M1 (n=5) control mAb (n=5)

AGAb serum levels (μg/ml)

0.26 ± 0.02

0.21 ± 0.04

0.42 ± 0.017

0.43 ± 0.023

M1 antibody serum levels (μg/ml)

5656 ± 518.7***

0.0 ± 0.0

4116 ± 496.4***

0.0 ± 0.0

C1q serum levels (μg/ml)

0.83 ± 0.5**

21.25 ± 3.6

1.175 ± 0.56**

15.08 ± 2.2

  1. All values indicate mean ± SEM, **p<0.01, ***p<0.001 compared to control mAb per model, unpaired students t-test
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Acta Neuropathologica Communications

ISSN: 2051-5960

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