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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

Fig. 4

Immune cell infiltration in acute MFS and AMAN models. a In the MFS model of disease, there was significantly less CD11b positive cells per field of view (FOV) within the proximity of the NMJ in animals who were treated with anti-C1q antibody. b No significance in NIMP-R positive cells existed between the two groups, despite a trend towards lower numbers in the anti-C1q antibody treated group. c In the AMAN model of disease, there was no significant difference between anti-C1q antibody treated and control mAb-treated animals in either CD11b or (d) NIMP-R14 positive cells. Neutrophils appeared to be absent within the proximity of the NMJ in this model. Bars represent mean ± SEM, *p < 0.05, unpaired student t-test. Scale bars = 20 μm. nAChR = nicotinic acetylcholine receptor

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Acta Neuropathologica Communications

ISSN: 2051-5960

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