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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation

Fig. 6

Immunohistochemistry of the mitochondrial proteins frataxin and ATP5B in DRG of normal controls and FA. a-b normal controls; c-d FA. a and c frataxin; b and d ATP5B. In a normal control DRG, frataxin reaction product is very prominent only in the neuronal cytoplasm (inset) whereas satellite and other cells in the space between neurons are almost devoid of immunoreactivity (a). In FA, satellite cells express abundant frataxin (c). The inset in (c) shows a neuron (N) that is devoid of frataxin while surrounding satellite cells are immunoreactive (inset, arrows). Similar to frataxin, ATP5B reaction product in mitochondria is prominent in neuronal cytoplasm of normal DRG (b, and inset). In FA, ATP5B reaction product continues to be present in the remaining small neurons but is more prominent in satellite cells (d, arrow, and inset). Bars (a-d), 50 μm; insets, 10 μm

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