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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation

Fig. 4

Immunohistochemistry of inflammatory cells in DRG of normal controls and FA. a-b normal controls; c-d FA; a and c CD68; b and d IBA1. a and b show the relative abundance of CD68- and IBA1-immunoreactive cells in normal DRG. Monocytes abut normal neurons (N) ([a and b], insets) but do not penetrate into the neuronal cytoplasm. In FA, a neuron shows invasion by CD68-positive monocytes resembling neuronophagia (inset) (c). Multiple IBA1-positive monocytes lie immediately adjacent to a degenerating nerve cell (N) (d). One ameboid monocyte appears to project thin processes along and through the neuronal plasma membrane (d, inset). Bars: (a-d), 100 μm; (a) and (c), insets, 20 μm; (b) and (d), insets, 10 μm

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