Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation

Fig. 1

Immunohistochemistry of glutamine synthetase, S100, and laminin in DRG of normal controls and FA. a-c normal controls; d-f FA; a and d glutamine synthetase; b and e S100; c and f laminin. In normal DRG, reaction product of glutamine synthetase (a) and S100 (b) reveal well organized layers of adjacent and overlapping satellite cells around each neuron. Normal nerve cells are surrounded by delicate layers of laminin (c). In FA, the remaining neurons are smaller, and satellite cell layers are thicker (d and e, insets) and disrupted (d, inset). Laminin reaction product shows multiple layers surrounding neurons, which is consistent with proliferation of satellite cell processes (f, inset). The arrows in (d) and (e) point to residual nodules that are reactive with antibodies to glutamine synthetase (d) and S100 (e), respectively. Bars: (a-f), 100 μm; insets, 20 μm

Back to article page