Case
|
Age
|
Sex
|
Mutational analysis
|
Immunohistochemistry
|
---|
CTNNB1 exon 3
|
BRAF exon 15
|
BRAF Pyro
|
VE1
|
nuclear β-catenin
|
---|
pap1
|
37
|
f
|
wt
|
V600E
|
V600E
|
+
|
neg
|
pap2
|
52
|
m
|
wt
|
V600E
|
-
|
-
|
neg
|
pap3
|
19
|
m
|
wt
|
V600E
|
-
|
-
|
neg
|
pap4d,e
|
49
|
f
|
wt
|
V600E
|
V600E
|
++
|
neg
|
pap5
|
43
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap6
|
57
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap7d,e
|
42
|
m
|
wt
|
V600E
|
V600E
|
++
|
neg
|
pap8d
|
46
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap9d,e
|
58
|
m
|
wt
|
V600E
|
V600E
|
++
|
neg
|
pap10
|
40
|
m
|
wt
|
V600E
|
V600E
|
+
|
neg
|
pap11b,d,e
|
38
|
m
|
wt
|
V600E
|
-
|
-
|
neg
|
pap12
|
57
|
m
|
wt
|
V600E
|
-
|
-
|
neg
|
pap13d,e
|
39
|
m
|
wt
|
V600E
|
V600E
|
++
|
neg
|
pap14
|
61
|
f
|
wt
|
V600E
|
-
|
-
|
-
|
pap15
|
56
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap16d,e
|
45
|
m
|
wt
|
V600E
|
-
|
-
|
neg
|
pap17
|
62
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap18d,e
|
36
|
m
|
wt
|
V600E
|
V600E
|
+
|
neg
|
pap19d,e
|
40
|
m
|
wt
|
V600E
|
V600E
|
-
|
neg
|
pap20d
|
36
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap21e
|
48
|
f
|
wt
|
V600E
|
V600E
|
+
|
neg
|
pap22e
|
48
|
f
|
-
|
-
|
V600E
|
++
|
neg
|
pap23e
|
34
|
m
|
wt
|
V600E
|
V600E
|
++
|
neg
|
pap24
|
43
|
m
|
wt
|
V600E
|
-
|
-
|
neg
|
pap25
|
41
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap26
|
47
|
f
|
wt
|
V600E
|
V600E
|
-
|
neg
|
pap27
|
34
|
f
|
wt
|
V600E
|
-
|
-
|
neg
|
pap28
|
74
|
m
|
wt
|
V600E
|
V600E
|
-
|
neg
|
pap29a,e
|
53
|
f
|
-
|
-
|
-
|
-
|
-
|
pap30a,e
|
41
|
f
|
-
|
-
|
-
|
-
|
-
|
pap31a,e
|
51
|
f
|
wt
|
-
|
V600E
|
-
|
-
|
pap32a 2
|
50
|
m
|
wt
|
-
|
V600E
|
-
|
-
|
pap33a,e
|
23
|
f
|
wt
|
-
|
V600E
|
-
|
-
|
pap34a,e
|
69
|
f
|
wt
|
-
|
V600E
|
-
|
-
|
pap35a,e
|
50
|
f
|
-
|
-
|
V600E
|
-
|
-
|
ada1
|
33
|
m
|
S33C
|
wt
|
-
|
-
|
neg
|
ada2
|
26
|
f
|
S33P
|
wt
|
-
|
-
|
pos
|
ada3
|
33
|
f
|
G34V
|
wt
|
-
|
-
|
pos
|
ada4
|
42
|
m
|
S33A; S33C
|
wt
|
-
|
-
|
pos
|
ada5
|
14
|
f
|
S37Y
|
wt
|
-
|
-
|
pos
|
ada6d,e
|
14
|
m
|
T41I
|
wt
|
-
|
-
|
pos
|
ada7c
|
61
|
f
|
S45P
|
wt
|
-
|
-
|
neg
|
ada8c
|
47
|
f
|
S45P
|
wt
|
-
|
-
|
pos
|
ada9
|
2
|
f
|
T41I
|
wt
|
-
|
-
|
pos
|
ada10
|
3
|
m
|
D32H
|
wt
|
-
|
-
|
pos
|
ada11d,e
|
11
|
m
|
T41I
|
wt
|
wt
|
-
|
pos
|
ada12
|
64
|
f
|
S45F
|
wt
|
-
|
-
|
pos
|
ada13
|
77
|
m
|
S33A
|
wt
|
-
|
-
|
-
|
ada14
|
20
|
m
|
A32F
|
wt
|
-
|
-
|
pos
|
ada15
|
49
|
m
|
G34R
|
wt
|
-
|
-
|
pos
|
ada16d,e
|
56
|
m
|
S33F
|
wt
|
wt
|
-
|
pos
|
ada17
|
21
|
f
|
S33Y
|
wt
|
-
|
-
|
pos
|
ada18
|
70
|
m
|
S33C
|
wt
|
-
|
-
|
pos
|
ada19d,e
|
9
|
f
|
S33C; T41S
|
wt
|
-
|
-
|
pos
|
ada20
|
8
|
m
|
S33C
|
wt
|
-
|
-
|
pos
|
ada21d,e
|
15
|
m
|
T41I
|
wt
|
-
|
-
|
pos
|
ada22
|
54
|
f
|
S33F
|
wt
|
-
|
-
|
pos
|
ada23
|
4
|
f
|
S37F
|
wt
|
-
|
-
|
pos
|
ada24
|
52
|
f
|
G34C
|
wt
|
wt
|
-
|
pos
|
ada25
|
51
|
m
|
G34R
|
wt
|
-
|
-
|
pos
|
ada26
|
47
|
f
|
T41I
|
wt
|
-
|
-
|
pos
|
ada27
|
43
|
f
|
G34V
|
wt
|
-
|
-
|
neg
|
ada28
|
48
|
f
|
T41I
|
wt
|
-
|
-
|
pos
|
ada29d,e
|
66
|
m
|
T41I
|
wt
|
wt
|
-
|
pos
|
ada30d
|
11
|
f
|
T41A
|
wt
|
wt
|
-
|
pos
|
ada31d,e
|
7
|
m
|
G34R
|
wt
|
-
|
-
|
pos
|
ada32d,e
|
50
|
m
|
I35S
|
wt
|
wt
|
-
|
pos
|
ada33d,e
|
15
|
f
|
T41A
|
wt
|
wt
|
-
|
pos
|
ada34
|
6
|
f
|
I35I; S37F
|
wt
|
-
|
-
|
pos
|
ada35
|
57
|
f
|
D32Y
|
wt
|
-
|
-
|
pos
|
ada36
|
58
|
f
|
S33C
|
wt
|
-
|
-
|
pos
|
ada37d,e
|
32
|
m
|
D32V
|
wt
|
-
|
-
|
pos
|
ada38
|
28
|
m
|
D32N
|
wt
|
-
|
-
|
pos
|
ada39
|
6
|
m
|
G34V
|
wt
|
-
|
-
|
pos
|
ada40
|
66
|
f
|
S37C
|
wt
|
-
|
-
|
pos
|
ada41
|
48
|
m
|
S37F
|
wt
|
-
|
-
|
-
|
ada42
|
67
|
m
|
G34R
|
wt
|
-
|
-
|
pos
|
ada43
|
3
|
f
|
S37F
|
wt
|
wt
|
-
|
pos
|
ada44
|
47
|
f
|
S33C
|
wt
|
-
|
-
|
pos
|
ada45
|
64
|
m
|
S33C
|
wt
|
-
|
-
|
pos
|
ada46e
|
3
|
m
|
S33F
|
wt
|
wt
|
-
|
pos
|
ada47
|
5
|
f
|
G34V
|
wt
|
-
|
-
|
pos
|
ada48d,e
|
59
|
m
|
S33C
|
wt
|
wt
|
-
|
pos
|
ada49
|
72
|
m
|
S37V
|
wt
|
-
|
-
|
pos
|
ada50
|
4
|
f
|
D32H
|
wt
|
-
|
-
|
pos
|
ada51
|
53
|
m
|
S33C
|
wt
|
-
|
-
|
-
|
ada52
|
45
|
m
|
T41I
|
wt
|
-
|
-
|
pos
|
ada53d,e
|
38
|
f
|
S33C
|
wt
|
wt
|
-
|
pos
|
ada54d,e
|
16
|
f
|
D32N
|
wt
|
wt
|
-
|
pos
|
ada55
|
38
|
f
|
T41I
|
wt
|
-
|
-
|
pos
|
ada56d,e
|
39
|
m
|
S33C
|
wt
|
wt
|
-
|
pos
|
ada57
|
61
|
f
|
S33C
|
wt
|
-
|
-
|
pos
|
ada58d,e
|
58
|
m
|
S33A
|
wt
|
wt
|
-
|
pos
|
ada59d,e
|
45
|
m
|
36_37del
|
wt
|
wt
|
-
|
pos
|
ada60e
|
48
|
m
|
D32Y
|
wt
|
-
|
-
|
pos
|
ada61
|
28
|
m
|
S33C
|
wt
|
-
|
-
|
pos
|
ada62
|
64
|
f
|
T41A
|
wt
|
-
|
-
|
-
|
ada63
|
53
|
f
|
S33C
|
wt
|
-
|
-
|
pos
|
ada64
|
9
|
m
|
S33F
|
wt
|
-
|
-
|
pos
|
ada65
|
8
|
f
|
S33C
|
wt
|
-
|
-
|
pos
|
ada66e
|
50
|
f
|
D32H
|
wt
|
wt
|
-
|
pos
|
ada67
|
20
|
f
|
T41I
|
wt
|
-
|
-
|
pos
|
ada68
|
50
|
m
|
S33C
|
wt
|
-
|
-
|
pos
|
ada69
|
25
|
f
|
D32H
|
wt
|
-
|
-
|
pos
|
ada70d,e
|
37
|
m
|
D32H
|
wt
|
wt
|
-
|
pos
|
ada71
|
12
|
f
|
T41I
|
wt
|
wt
|
-
|
pos
|
ada72
|
54
|
m
|
del-85bp
|
wt
|
-
|
-
|
pos
|
ada73
|
27
|
f
|
S33C
|
wt
|
-
|
-
|
pos
|
ada74
|
61
|
f
|
D32F
|
wt
|
-
|
-
|
pos
|
ada75e
|
37
|
m
|
35-46del
|
wt
|
wt
|
-
|
pos
|
ada76e
|
51
|
m
|
D32Y
|
wt
|
wt
|
-
|
pos
|
ada77
|
63
|
m
|
S33F
|
wt
|
-
|
-
|
pos
|
ada78e
|
9
|
f
|
-
|
-
|
-
|
-
|
pos
|
ada79e
|
9
|
f
|
S33F
|
-
|
wt
|
-
|
pos
|
ada80a e
|
9
|
f
|
T41A
|
-
|
wt
|
-
|
-
|
- Age illustrates time at tumor surgery. Samples were screened for CTNNB1 and BRAF mutation using different standard techniques
-
VE1 BRAF V600E specific antibody, m male, f female, wt wild type, pos positive, neg negative, Pyro Pyrosequencing
-
aPatient cohort under study comprising tissue specimens of papillary (pap) and adamantinomatous (ada) craniopharyngiomas (CP), collected from the archives of the Departments of Neuropathology in Erlangen and Heidelberg
-
b = unclear CP subtype, − = not analysed, c = samples of one patient with a recurrent tumor after 14 years
-
dsamples subject to analyses of gene expression using Affymetrix U133 Plus2.0 expression array or e450 k Illumina methylation array