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Table 1 Summary of mutational and immunohistochemical analyses

From: Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

Case Age Sex Mutational analysis Immunohistochemistry
CTNNB1 exon 3 BRAF exon 15 BRAF Pyro VE1 nuclear β-catenin
pap1 37 f wt V600E V600E + neg
pap2 52 m wt V600E - - neg
pap3 19 m wt V600E - - neg
pap4d,e 49 f wt V600E V600E ++ neg
pap5 43 f wt V600E - - neg
pap6 57 f wt V600E - - neg
pap7d,e 42 m wt V600E V600E ++ neg
pap8d 46 f wt V600E - - neg
pap9d,e 58 m wt V600E V600E ++ neg
pap10 40 m wt V600E V600E + neg
pap11b,d,e 38 m wt V600E - - neg
pap12 57 m wt V600E - - neg
pap13d,e 39 m wt V600E V600E ++ neg
pap14 61 f wt V600E - - -
pap15 56 f wt V600E - - neg
pap16d,e 45 m wt V600E - - neg
pap17 62 f wt V600E - - neg
pap18d,e 36 m wt V600E V600E + neg
pap19d,e 40 m wt V600E V600E - neg
pap20d 36 f wt V600E - - neg
pap21e 48 f wt V600E V600E + neg
pap22e 48 f - - V600E ++ neg
pap23e 34 m wt V600E V600E ++ neg
pap24 43 m wt V600E - - neg
pap25 41 f wt V600E - - neg
pap26 47 f wt V600E V600E - neg
pap27 34 f wt V600E - - neg
pap28 74 m wt V600E V600E - neg
pap29a,e 53 f - - - - -
pap30a,e 41 f - - - - -
pap31a,e 51 f wt - V600E - -
pap32a 2 50 m wt - V600E - -
pap33a,e 23 f wt - V600E - -
pap34a,e 69 f wt - V600E - -
pap35a,e 50 f - - V600E - -
ada1 33 m S33C wt - - neg
ada2 26 f S33P wt - - pos
ada3 33 f G34V wt - - pos
ada4 42 m S33A; S33C wt - - pos
ada5 14 f S37Y wt - - pos
ada6d,e 14 m T41I wt - - pos
ada7c 61 f S45P wt - - neg
ada8c 47 f S45P wt - - pos
ada9 2 f T41I wt - - pos
ada10 3 m D32H wt - - pos
ada11d,e 11 m T41I wt wt - pos
ada12 64 f S45F wt - - pos
ada13 77 m S33A wt - - -
ada14 20 m A32F wt - - pos
ada15 49 m G34R wt - - pos
ada16d,e 56 m S33F wt wt - pos
ada17 21 f S33Y wt - - pos
ada18 70 m S33C wt - - pos
ada19d,e 9 f S33C; T41S wt - - pos
ada20 8 m S33C wt - - pos
ada21d,e 15 m T41I wt - - pos
ada22 54 f S33F wt - - pos
ada23 4 f S37F wt - - pos
ada24 52 f G34C wt wt - pos
ada25 51 m G34R wt - - pos
ada26 47 f T41I wt - - pos
ada27 43 f G34V wt - - neg
ada28 48 f T41I wt - - pos
ada29d,e 66 m T41I wt wt - pos
ada30d 11 f T41A wt wt - pos
ada31d,e 7 m G34R wt - - pos
ada32d,e 50 m I35S wt wt - pos
ada33d,e 15 f T41A wt wt - pos
ada34 6 f I35I; S37F wt - - pos
ada35 57 f D32Y wt - - pos
ada36 58 f S33C wt - - pos
ada37d,e 32 m D32V wt - - pos
ada38 28 m D32N wt - - pos
ada39 6 m G34V wt - - pos
ada40 66 f S37C wt - - pos
ada41 48 m S37F wt - - -
ada42 67 m G34R wt - - pos
ada43 3 f S37F wt wt - pos
ada44 47 f S33C wt - - pos
ada45 64 m S33C wt - - pos
ada46e 3 m S33F wt wt - pos
ada47 5 f G34V wt - - pos
ada48d,e 59 m S33C wt wt - pos
ada49 72 m S37V wt - - pos
ada50 4 f D32H wt - - pos
ada51 53 m S33C wt - - -
ada52 45 m T41I wt - - pos
ada53d,e 38 f S33C wt wt - pos
ada54d,e 16 f D32N wt wt - pos
ada55 38 f T41I wt - - pos
ada56d,e 39 m S33C wt wt - pos
ada57 61 f S33C wt - - pos
ada58d,e 58 m S33A wt wt - pos
ada59d,e 45 m 36_37del wt wt - pos
ada60e 48 m D32Y wt - - pos
ada61 28 m S33C wt - - pos
ada62 64 f T41A wt - - -
ada63 53 f S33C wt - - pos
ada64 9 m S33F wt - - pos
ada65 8 f S33C wt - - pos
ada66e 50 f D32H wt wt - pos
ada67 20 f T41I wt - - pos
ada68 50 m S33C wt - - pos
ada69 25 f D32H wt - - pos
ada70d,e 37 m D32H wt wt - pos
ada71 12 f T41I wt wt - pos
ada72 54 m del-85bp wt - - pos
ada73 27 f S33C wt - - pos
ada74 61 f D32F wt - - pos
ada75e 37 m 35-46del wt wt - pos
ada76e 51 m D32Y wt wt - pos
ada77 63 m S33F wt - - pos
ada78e 9 f - - - - pos
ada79e 9 f S33F - wt - pos
ada80a e 9 f T41A - wt - -
  1. Age illustrates time at tumor surgery. Samples were screened for CTNNB1 and BRAF mutation using different standard techniques
  2. VE1 BRAF V600E specific antibody, m male, f female, wt wild type, pos positive, neg negative, Pyro Pyrosequencing
  3. aPatient cohort under study comprising tissue specimens of papillary (pap) and adamantinomatous (ada) craniopharyngiomas (CP), collected from the archives of the Departments of Neuropathology in Erlangen and Heidelberg
  4. b = unclear CP subtype, − = not analysed, c = samples of one patient with a recurrent tumor after 14 years
  5. dsamples subject to analyses of gene expression using Affymetrix U133 Plus2.0 expression array or e450 k Illumina methylation array
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Acta Neuropathologica Communications

ISSN: 2051-5960

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