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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

Fig. 3

Comparison of adaCP and papCP methylation and gene expression profile. Volcano plot (a) showing the difference in median methylation of genes between adaCP (n = 17) and papCP (n = 8) samples on the x-axis and the –log10 transformed p-values of the corresponding t-test results on the y-axis. The volcano plot on the right hand side shows the difference in mean gene expression of genes between adaCP and papCP samples on the x-axis and corresponding –log10 transformed t-test p-values on the y-axis. Genes significantly differentially methylated and differentially expressed are marked red. AXIN2, PTCH1 and GLI2, indicated in blue, are significantly hypomethylated and show an increased gene expression in adaCP samples. (b) Plotting of tumor specific AXIN2, GLI2 and PTCH1 methylation values (beta scale, x-axis) and gene expression values (log2, y-axis) revealed a significant different clustering of adaCP and papCP subtypes. Corresponding box plots clearly emphasize that there is an inverse correlation between gene expression and methylation

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