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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

Fig. 7

Reduction of ErbB3 expression in the lumbar motor neurons of SOD1G93A mice. (ad) The lumbar spinal cord sections from 5 months old wild-type mice were stained with the antibodies for ErbB3, VAChT, GFAP, and NeuN. The representative images for motor neurons stained with VAChT/ErbB3 (a) with corresponding magnified Z axis-images of the C-bouton (b, arrow). Bar: 10 μm. (c, d) Images for the lumbar spinal cord sections from 5 months old wild-type mice stained with the antibodies for ErbB3 and NeuN (c), or ErbB3, ChAT, and GFAP (d). Arrowhead and inset indicate ErbB3 expressions in ChAT-positive partition cells and their magnified image, respectively. Bars: 200 μm (c, d). (eh) The lumbar spinal cord sections from 5 months old wild-type (WT; e) or SOD1G93A mice at 3 (f), 3.5 (g) and 5 months old (h) were stained with the antibodies for ErbB3, VAChT, and NeuN. Representative images in the anterior horn area were shown with the merged images. Arrows indicate the motor neurons surrounded by VAChT-positive puncta showed diminished levels of ErbB3. Arrowheads show the VAChT-negative, non-motor neurons with preserved ErbB3 expressions in SOD1G93A mice. Bar: 50 μm (eh)

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