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Table 4 Endpoint titration of isolated T1Ov and T2Ov MM2-sCJD prions in ovine PrP mice

From: Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions

Inoculum

Dilution

Mean incubation timea (n/n0)

  

T2Ov b

T1Ov b

MM2-sCJD

10−4

142 ± 8 (5/5)

nd

 

10−5

146 (1/6)

148 ± 4 (6/6)

 

10−6

174; 192 (2/6)c

212 ± 6 (3/6)c

 

10−7

> 450 (0/6)c

> 450 (0/6)c

 

10−8

>450 (0/6)c

> 450 (0/6)c

  1. n/n0: number of mice with neurological disease and positive for PrPres in the brain by immunoblotting/number of inoculated mice
  2. aDays ± SE of the mean.
  3. bThe T2Ov and T1Ov brain material were from tg338-cloned MM2-sCJD prions and from PMCA MM2-sCJD prions, respectively.
  4. congoing experiment
  5. nd: not done
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Acta Neuropathologica Communications

ISSN: 2051-5960

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