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Table 4 Endpoint titration of isolated T1Ov and T2Ov MM2-sCJD prions in ovine PrP mice

From: Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions

Inoculum Dilution Mean incubation timea (n/n0)
   T2Ov b T1Ov b
MM2-sCJD 10−4 142 ± 8 (5/5) nd
  10−5 146 (1/6) 148 ± 4 (6/6)
  10−6 174; 192 (2/6)c 212 ± 6 (3/6)c
  10−7 > 450 (0/6)c > 450 (0/6)c
  10−8 >450 (0/6)c > 450 (0/6)c
  1. n/n0: number of mice with neurological disease and positive for PrPres in the brain by immunoblotting/number of inoculated mice
  2. aDays ± SE of the mean.
  3. bThe T2Ov and T1Ov brain material were from tg338-cloned MM2-sCJD prions and from PMCA MM2-sCJD prions, respectively.
  4. congoing experiment
  5. nd: not done