Skip to main content

Table 2 Endpoint titration of serially passaged MM2-sCJD prions in human or ovine PrP mice

From: Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions

Inoculum Dilution Mean incubation timea (n/n0)
   tg650 (human PrP) tg338 (ovine PrP)
MM2-sCJDb 10−4 351 ± 6 (5/5) nd
  10−5 441 ± 51 (3/5) 163 ± 10 (6/6)
  10−6 424; 501 (2/6) 227 ± 22 (4/6)
  10−7 >600 (0/6) > 500 (0/6)
  10−8 >600 (0/6) >500 (0/6)
  1. n/n0: number of mice with neurological disease and positive for PrPres in the brain by immunoblotting/number of inoculated mice
  2. aDays ± SE of the mean.
  3. bMM2-sCJD iteratively passaged in either tg650 or tg338 mice.
  4. nd: not done