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Table 1 Serial transmission of MM2-cortical sCJD to mice expressing human or ovine PrP

From: Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions

Inoculum Passage Mean incubation timeb (n/n0)
   tg650 (human PrP) tg338 (ovine PrP)
MM2-sCJD 1 278 ± 6 (6/6) 557 ± 11 (6/7)
  2 274 ± 4 (8/8) 84 ± 1 (6/6)
  3 280 ± 4 (12/12) 81 ± 2 (6/6)
  4 268 ± 4 (8/8)a 78 ± 2 (7/7)
  5 nd 80 ± 1 (6/6)
  1. n/n0: number of mice with neurological disease and positive for PrPres in the brain by immunoblotting/number of inoculated mice
  2. aSubpassage after cloning by end-point titration
  3. bDays ± SE of the mean.
  4. nd: not done