Fig. 3

After 12 weeks high fat feeding, female Sorcs1 -/- x APP/PSEN1 mice demonstrate greater impairment in glucose intolerance and insulin sensitivity than Sorcs1 -/- mice. Glucose tolerance testing (a, c), insulin tolerance testing (b, d) fasting plasma insulin (e, g), fasting plasma glycerol (f, h), fasting plasma non-esterified free fatty acids; NEFA (i, k), fasting plasma triglycerides (j, l), branched-chain amino acids; BCAAs (m, o) and body weight (n, p) in cohorts of male and Female WT (n = 5–12/group), Sorcs1 -/- (n = 10–16/group), APP/PSEN1 (n = 6–7/group) and Sorcs1 -/- x APP/PSEN1 (n = 4–9/group). Cohorts were maintained on standard rodent chow from weaning until 6 mo when they were placed on a 60 % high fat diet for 12 weeks. a-d two-way ANOVA with Bonferroni posthoc analyses; *P < 0.05, **P < 0.01 and ***P < 0.001 green = Sorcs1 -/- versus WT, blue = APP/PSEN1 versus WT, red = Sorcs1 -/- x APP/PSEN1 versus WT, ^# P < 0.05 and ^## P < 0.01 red = Sorcs1 -/- versus Sorcs1 -/- x APP/PSEN1, ^&& P < 0.01 and ^&&& P < 0.001 blue = Sorcs1 -/- versus APP/PSEN1. e-p one-way ANOVA with Bonferroni posthoc analyses; *P < 0.05. Data expressed as mean ± s.e.m