Fig. 2

After 4 weeks high fat feeding, male but not female APP/PSEN1, Sorcs1 -/- and Sorcs1 -/- x APP/PSEN1 mice demonstrate impaired glucose homeostasis compared to WT mice. Glucose tolerance testing (a-b), insulin tolerance testing (c) fasting plasma insulin (d, f), fasting plasma glycerol (e, g), fasting plasma non-esterified free fatty acids; NEFA (h, j), fasting plasma triglycerides (i, k), fasting plasma branched-chain amino acids; BCAA (l, n) body weight (m, o), lean mass (p, r) and fat mass (q, s) in cohorts of male and female WT (n = 5–12/group), Sorcs1 -/- (n = 10–16/group), APP/PSEN1 (n = 6–7/group) and Sorcs1 -/- x APP/PSEN1 (n = 4–9/group). Cohorts were maintained on standard rodent chow from weaning until 6 mo when they were placed on a 60 % high fat diet for 4 weeks. a-c two-way ANOVA with Bonferroni posthoc analyses; *P < 0.05, **P < 0.01 and ***P < 0.001 green = Sorcs1 -/- versus WT, blue = APP/PSEN1 versus WT, red = Sorcs1 -/- x APP/PSEN1 versus WT, ^# P < 0.05 blue = APP/PSEN1 versus Sorcs1 -/- x APP/PSEN1, ^& P < 0.05 blue = Sorcs1 -/- versus APP/PSEN1. d-s one-way ANOVA with Bonferroni posthoc analyses; *P < 0.05 and **P < 0.01. Data expressed as mean ± s.e.m