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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

Fig. 7

Inflammation vs. Tau pathology. a-b Paraffin sections of 12 months old hTau40AT and WT mice were co-stained for neuroinflammation (GFAP or Iba1; brown) and Tau-phosphorylation (AT8; blue) or neuroinflammation (GFAP or Iba1, brown) and Tau-aggregation (Gallyas silver; black). Note the accumulation of glial cells in the surrounding of hippocampal neurons bearing pathological, AT8-phosphorylated Tau (a2 and b2, arrows) or NFTs (a4 and b5-6, arrows) in hTau40AT mice. Age-matched controls show no AT8-staining, no NFTs and only a few astrocytes and microglia (a1, a3, b1, b3-4). Red-boxed areas (b3, b5) indicate close-ups (b4, b6). WT: wildtype; A152T: hTau40AT transgenic mouse strain; CA: cornu ammonis; Ctx: cortex; DG: dentate gyrus; mo: months; Scale bar: 25 μm (a3-4, b1-2), 50 μm (a1-2, b3-6)

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