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Fig. 11 | Acta Neuropathologica Communications

Fig. 11

From: Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

Fig. 11

Diagram of progression of neuropathology in hTau40AT mice. Continuous expression and accumulation of hTau40AT in brain and spinal cord of hTau40AT mice lead to early pathologic changes at 2–3 months of age, including Tau-phosphorylation, Tau-mislocalization into the somatodendritic compartment and Tau-co-aggregation of endogenous mouse Tau and exogenous hTau40AT into pretangles. At 3–4 months of age, initial mature tangles (NFTs) are detected by Gallyas silver and ThS staining. Neuroinflammatory processes start from 5 months onwards. Progressive Tau-phosphorylation, Tau-co-aggregation and neuroinflammation likely cause neurotoxic events, resulting in synaptic decay, neurodegeneration and cognitive decline of aged hTau40AT mice. In parallel, progressive neuroinflammation might alter protein degradation systems, inducing autophagy and reducing proteasome activity in aging hTau40AT mice. mo: months

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