Skip to main content
Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

Fig. 10

Cognitive impairment of hTau40AT mice at 16 months of age. Morris water maze (MWM) test of 10 and 16 months old hTau40AT mice in comparison to age-matched WT littermates. a, b At 10 months of age, spatial learning of hTau40AT mice during a MWM acquisition is similar to WT controls and (b) hTau40AT mice show a high preference for the target quadrant (>40 %), which is comparable to controls throughout all probe trials, indicating preservation of cognitive functions at 10 months of age. c In contrast, 16 months old hTau40AT mice are impaired in learning the position of the hidden platform as demonstrated by significantly increased escape latencies during MWM acquisition in comparison to control mice (interaction effect, genotype x day, p = 0.033, F(4,116) = 2.72). d Moreover hTau40AT mice exhibit a lower preference for the target quadrant than WT animals from probe trial 2 onwards, pointing towards severe short- and long-term memory deficits due to accumulation of hTau40AT at advanced age. a, c Data show mean escape latency (s) ± SEM for 10 months old WT (n = 14) vs hTau40AT mice (n = 18) and 16 months old WT (n = 11) vs hTau40AT mice (n = 20). Statistics: two-way repeated measure analysis of variances with post hoc Fishers LSD multiple comparisons test. Asterisks indicate a significant effect of interaction (genotype x day) between hTau40AT mice and control group, *:p < 0.05. b, d Bars represent mean time in target quadrant (%) ± SEM for 10 months old WT (n = 14) vs hTau40AT mice (n = 18) and 16 months old WT (n = 11) vs hTau40AT mice (n = 20). Statistics: two-tailed Students t-test between hTau40AT mice and control group for each probe trial, *:p < 0.05, ***:p < 0.001; n: number of mice; WT: wild-type animals; mo: months of age

Back to article page