Fig. 8From: New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analysesImmunolocalization of proteins involved in unfolded protein response (UPR), oxidative stress response and transcription regulation. Serial skeletal muscle cryosections from a myotilinopathy patient (ID1 in Table 1) were double-stained with antibodies recognizing GRP78/BiP, thrombospondin 4 (both involved in UPR), MGST3 (related to oxidative stress response), and YBX3 (transcription regulation) and either filamin C or myotilin. Nuclei were visualized by DAPI staining. Results of semiquantitative evaluation of signal intensities in the different abnormal areas A1–A3 are specified in Table 3. Scale bar = 50 μmBack to article page