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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses

Fig. 7

Immunolocalization of proteins involved in chaperone-assisted selective autophagy (CASA) and NBR1-mediated selective autophagy. Serial skeletal muscle cryosections from a myotilinopathy patient (ID1 in Table 1) were double-stained with antibodies recognizing the indicated CASA components (BAG3, HSPB8/Hsp22, HSPA8/Hsc70, p62) and NBR1 and either filamin C or myotilin. Nuclei were visualized by DAPI staining. Results of semiquantitative evaluation of signal intensities in the different abnormal areas A1–A3 are specified in Table 3. Scale bar = 50 μm

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