Fig. 2

Functional classification and interactions of proteins identified as over-represented in myotilinopathy aggregates samples. a Results of proteomic analysis in myotilinopathy. Proteins identified as over-represented in aggregate samples by mass spectrometric analysis are grouped with regard to their localization or main function. Shown are proportions in aggregate and control samples. Z-disc (−associated) proteins constituted the most abundant group of over-represented proteins, followed by proteins of the sarcolemma and extracellular matrix (ECM), proteins involved in protein quality control and degradation and proteins with a function in actin dynamics or cytoskeletal transport. b Schematic illustration of over-represented proteins which were verified by immunofluorescence studies and of protein-protein interactions. Each protein is termed by the name of its encoding gene (see Additional file 2: Table S2). Direct protein interactions, identified by review of the literature, are depicted by solid connecting lines. Indirect protein interactions are depicted by a dashed connecting line