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Fig. 11 | Acta Neuropathologica Communications

Fig. 11

From: New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses

Fig. 11

Immunolocalization of sarcolemmal proteins. Double immunofluorescence staining was performed on serial skeletal muscle cryosections from a myotilinopathy patient (ID1 in Table 1) by using antibodies directed against the sarcolemmal proteins dystrophin, dysferlin, supervillain, and δ-sarcoglycan and either filamin C or myotilin. Nuclei were visualized by the blue-fluorescent DAPI nucleic acid stain. Data of semiquantitative assessment of immunofluorescence intensities in abnormal areas A1–A3 are listed in Table 3. Scale bar = 50 μm

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