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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase

Fig. 3

Heterozygous deletion of Becn1 impairs autophagy and exacerbates the disease course in hSOD1G127X mice. a Western blots for autophagic and lysosomal proteins in the spinal cords of hSOD1G127X/Becn1 +/- mice and littermates (n = 3 per genotype). bg The relative expression levels of (b) Beclin 1, (c) Atg12-Atg5, (d) LC3-II, (e) p62, (f) Lamp2, and (g) Cathepsin D in terminally ill mice. Data are given as mean ± SD. *P < 0.05 vs Non-Tg. **P < 0.01 vs Non-Tg. ## P < 0.01 vs. hSOD1G127X (one-way ANOVA with Tukey-Kramer’s test). N.S. not significant (vs. Non-Tg). hj The disease courses of hSOD1G127X mice (n = 13; male:female 7:6) and hSOD1G127X/Becn1 +/- mice (n = 14; male:female 7:7) were evaluated based on alterations in body weight. h Temporal changes in body weight of the mice. Statistical significance was analyzed using repeated-measures ANOVA. i Kaplan-Meier curves for disease onset and survival. Statistical significance was analyzed using repeated-measures ANOVA using Kaplan-Meier analysis with log-rank test. j Scatter plot for the disease duration. Bars represent mean values. **P < 0.01 (two-tailed Welch’s t-test)

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