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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase

Fig. 2

Autophagy factors become elevated in the spinal ventral horns and precentral gyrus of ALS patients. a, b Western blots for autophagic proteins in human postmortem specimens of (a) spinal ventral horns and (b) precentral gyrus from five non-neurological controls, four SALS patients, five FALS patients without SOD1 mutations including expanded hexanucleotide GGGGCC repeats in C9orf72 (n = 4), and nine FALS patients with SOD1 mutations including one A4V, one G72C, five D90A, and two G127X. Aliquots of protein extracts (20 μg) were loaded in each well. β-Actin was used as a loading marker. cj Scatter plots showing the expression levels of autophagic proteins in (cf) ventral horn and (gj) precentral gyrus. All values in each CNS region were normalized to the level of expression of the temporal lobe standard. Bars represent mean values. *P < 0.05 vs. controls. **P < 0.01 vs. controls. N.S. not significant (vs. controls). Statistical analysis was performed using one-way ANOVA with Tukey-Kramer’s test

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