Fig. 4

Gene expression profile heat map. A positive enrichment score (column Z-score) indicates the tumor sample expression profile and the genes in that particular gene set are positively correlated, whereas a negative enrichment score indicates the opposite. Five tumors demonstrated expression signatures enriched for one subtype, while the remaining three had transcriptional profiles enriched for two. Three tumors showed exclusive classification as the proneural subtype (cases 1, 2, and 6), and one tumor each was classified exclusively as classical and mesenchymal (cases 7 and 3, respectively). Cases 4 and 5 showed both classical and neural signatures, while case 8 showed both mesenchymal and neural subtype expression patterns