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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups

Fig. 3

Patterns of recurrent copy-number aberrations (CNAs) identified using Illumina microarray. Focal amplifications of 7p11.2 (EGFR) and gains of chr7 were present in 4/8 and 6/8 cases, respectively, and were mutually exclusive of 1p/19q co-deletion and IDH1 R132H mutation (cases 1 and 2). Loss of chr10 (PTEN) and homozygous 9p21.3 loss (CDKN2A) occurred in 4/4 and 2/4 cases with EGFR amplification, respectively. Focal gains involving 4q12 (PDGFRA) were present in 2 cases

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Acta Neuropathologica Communications

ISSN: 2051-5960

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