Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways

Table 2 Number of differentially expressed microRNAs in pediatric brain tumors compared to normal adult brain

Pathology	n	Regulation		Total
Pathology	n	Up	Down	Total
Pilocytic astrocytoma	14	42	49	91
Pilocytic astrocytoma^a	14	27	33	60
Diffuse astrocytoma	3	1	2	3
Anaplastic astrocytoma	2	6	8	14
Glioblastoma	5	0	5	5
Ependymoma	14	60	75	135
Medulloblastoma	9	25	35	60
Medulloblastoma^a	9	10	29	39
Atypical Teratoid/Rhabdoid tumor	5	15	17	32
Choroid plexus papilloma	4	47	63	110

^aPilocytic astrocytomas and medullobastomas were also compared to normal adult cerebellum. Fold change > 2 with a FDR corrected p-value < 0.05

ISSN: 2051-5960