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Table 6 Tumor grade is correlated with patient age within molecular subtypes of diffuse glioma

From: PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

 

Grade II

Grade III

Grade IV

P

P II v. III

Overall

39.6 ± 12.5 (137)

45.6 ± 13.5 (144)

61.3 ± 13 (261)

<0.0001

 

IDH1/IDH2

39.6 ± 12.3 (127)

42 ± 12.1 (102)

39.6 ± 15.7 (13)

0.32

0.14

CIC/FUBP1

42.3 ± 13.4 (37)

48 ± 10.8 (26)

 

0.065

0.065

LOH 1p19q

42 ± 12.4 (42)

49.4 ± 11.8 (32)

 

0.012

0.012

ATRX

37.4 ± 11.9 (67)

38.1 ± 11.3 (51)

41.6 ± 17.2 (14)

0.30

0.74

TP53

37.2 ± 11.8 (71)

39.9 ± 11.7 (74)

59.2 ± 15.5 (78)

<0.0001

0.18

EGFR

 

61.7 ± 7.5 (15)

61.2 ± 11.7 (69)

0.84

 

PTEN

 

56.8 ± 10.5 (12)

62.8 ± 11.9 (80)

0.092

 

alt 7/10

49.7 ± 8.3 (3)

59.4 ± 6.8 (26)

62.8 ± 10.8 (185)

0.015

 

NF1

51 ± 18.4 (3)

43.7 ± 12.7 (14)

64.4 ± 13.2 (27)

0.00050

 
  1. Values are listed as the mean patient age +/− standard deviation (number of tumors analysed). P values were calculated using an anova. P II v. III indicates significance of grade II v. grade III tumors based on a T-test. Total number of cases analysed = 542