Table 5 Tumor grade is correlated with mutational load within molecular subtypes of diffuse glioma

Overall

20.6 ± 10.6 (137)

32.4 ± 34.3 (144)

57.3 ± 19.9 (261)

<0.0001

IDH1/IDH2

21.1 ± 10.1 (127)

26.7 ± 12.1 (102)

52 ± 22.1 (13)

<0.0001

0.00023

CIC/FUBP1

21.9 ± 10.3 (37)

28 ± 10.7 (26)

0.030

LOH 1p19q

21.7 ± 10.1 (42)

28.2 ± 10.2 (32)

0.0081

ATRX

21.6 ± 10.3 (67)

26 ± 11.2 (51)

65.4 ± 40.1 (14)

<0.0001

0.034

TP53

21.4 ± 10.2 (71)

33 ± 46.1 (74)

60.5 ± 23 (78)

<0.0001

0.038

EGFR

41.9 ± 12.7 (15)

60.3 ± 16.6 (69)

<0.0001

PTEN

42.8 ± 10.8 (12)

62.7 ± 21.3 (80)

<0.0001

alt 7/10

24 ± 10.6 (3)

43.5 ± 10.1 (26)

59.6 ± 16.7 (185)

<0.0001

NF1

12 ± 7.2 (3)

57.6 ± 101.6 (14)

56.6 ± 15.5 (27)

0.97