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Table 3 Tumor grade is inversely correlated with survival within molecular subtypes of diffuse glioma

From: PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

 

Grade II

Grade III

Grade IV

  

Genes

OS (y)

n

OS (y)

n

OS (y)

n

P

P II vs III

IDH + CIC/FUBP1/LOH 1p19q

"not reached"

47

5.2

34

 

1

0.040

0.04

IDH + ATRX/TP53

7.3

73

5.2

70

2.8

13

0.0029

0.069

EGFR/PTEN/ alt 7/10

1.9

3

1.5

32

1.2

211

0.13

0.5

NF1

2.1

3

1.9

14

1

27

0.034

NA

  1. IDH + CIC/FUBP1/LOH 1p19q refers to mutations in IDH plus any of the subsequent genes, similar for IDH + ATRX/TP5 3. Statistical tests were performed using a Chi-square test. OS refers to median overall survival in years. Frequency comparisons were done between grade II, III and IV. Exceptions were made for genes with too few/no data in one of the grades (e.g. there are no grade IV tumors with 1p19q codeletion). Therefore, the P value for NF1 is based on comparison between grade III and IV and the P value for IDH + CIC/FUBP1/LOH 1p19q is based on a comparison between grade II and III
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Acta Neuropathologica Communications

ISSN: 2051-5960

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