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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

Fig. 2

Survival in prognostic molecular subtypes of diffuse glioma stratified by tumor grade. Different subtypes are indicated above each graph. As can be seen, within defined molecular subtypes, tumor grade remains a prognostic factor. Number of samples (grade II, III and IV) for each graph: 10, 42 and 248 (IDH-wt); 73, 65 and 13 (IDH-mut, ATRX/TP53 mut); 42, 32 and 0 (IDH-mut, 1p19q codeleted). 17 samples were IDH-mut but had neither ATRX/TP53 mutations nor 1p19q codeletion. P values indicated are calculated using the Log-rank test; other test for significance show for IDH-wt tumors a P = 0.0092 and for IDH-mut, ATRX/TP53 mut tumors a P = 0.0034 (both logrank test for trend); for IDH-mut, 1p19q codeleted) a P = 0.28 (Gehan Breslow Wilcoxon test). Log rank P values for grade II v. III are 0.43 and 0.063 for IDH-wt and IDH-mut, ATRX/TP53 mut tumors respectively

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