Fig. 2

Alpha-synuclein overexpression induces long-term inflammation in the striatum. a Immunohistochemical staining of striatal sections against Iba1 8 weeks after 6-OHDA injection or α-synuclein overexpression. Scale bar: 40 μm. b Striatal levels of IL1b, IL6, IL10, TNFα and IFNγ were measured by ELISA 8 weeks after 6-OHDA MFB lesion or intra-nigral injection of an AAV-α-synuclein vector. Cytokine levels are expressed relative to the control side. Data are expressed as mean ± SEM (n = 4 per group). *P < 0.05 and **P < 0.01 compared to 6-OHDA group (t-test)